Mutation Rate Inferred From Synonymous Substitutions in a Long-Term Evolution Experiment With Escherichia coli

The quantification of spontaneous mutation rates is crucial for a mechanistic understanding of the evolutionary process. In bacteria, traditional estimates using experimental or comparative genetic methods are prone to statistical uncertainty and consequently estimates vary by over one order of magn...

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Main Authors: Wielgoss, Sébastien, Barrick, Jeffrey E., Tenaillon, Olivier, Cruveiller, Stéphane, Chane-Woon-Ming, Béatrice, Médigue, Claudine, Lenski, Richard E., Schneider, Dominique
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2011
Teme:
Investigation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246271/
https://ncbi.nlm.nih.gov/pubmed/22207905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.111.000406
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