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Synonymous Genetic Variation in Natural Isolates of Escherichia coli Does Not Predict Where Synonymous Substitutions Occur in a Long-Term Experiment

Synonymous genetic differences vary by more than 20-fold among genes in natural isolates of Escherichia coli. One hypothesis to explain this heterogeneity is that genes with high levels of synonymous variation mutate at higher rates than genes with low synonymous variation. If so, then one would exp...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Maddamsetti, Rohan, Hatcher, Philip J., Cruveiller, Stéphane, Médigue, Claudine, Barrick, Jeffrey E., Lenski, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651231/
https://ncbi.nlm.nih.gov/pubmed/26199375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msv161
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