Mutation Rate Inferred From Synonymous Substitutions in a Long-Term Evolution Experiment With Escherichia coli

The quantification of spontaneous mutation rates is crucial for a mechanistic understanding of the evolutionary process. In bacteria, traditional estimates using experimental or comparative genetic methods are prone to statistical uncertainty and consequently estimates vary by over one order of magn...

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Main Authors: Wielgoss, Sébastien, Barrick, Jeffrey E., Tenaillon, Olivier, Cruveiller, Stéphane, Chane-Woon-Ming, Béatrice, Médigue, Claudine, Lenski, Richard E., Schneider, Dominique
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2011
Fag:
Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246271/
https://ncbi.nlm.nih.gov/pubmed/22207905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.111.000406
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