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Emerging roles of the FBW7 tumour suppressor in stem cell differentiation
FBW7 is a ubiquitin E3 ligase substrate adaptor that targets many important oncoproteins—such as Notch, c-Myc, cyclin E and c-Jun—for ubiquitin-dependent proteolysis. By doing so, it plays crucial roles in many cellular processes, including cell cycle progression, cell growth, cellular metabolism, d...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3246256/ https://ncbi.nlm.nih.gov/pubmed/22157894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.231 |
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