Emerging roles of the FBW7 tumour suppressor in stem cell differentiation

FBW7 is a ubiquitin E3 ligase substrate adaptor that targets many important oncoproteins—such as Notch, c-Myc, cyclin E and c-Jun—for ubiquitin-dependent proteolysis. By doing so, it plays crucial roles in many cellular processes, including cell cycle progression, cell growth, cellular metabolism, d...

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Dades bibliogràfiques
Autors principals: Wang, Zhiwei, Inuzuka, Hiroyuki, Fukushima, Hidefumi, Wan, Lixin, Gao, Daming, Shaik, Shavali, Sarkar, Fazlul H, Wei, Wenyi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Review Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246256/
https://ncbi.nlm.nih.gov/pubmed/22157894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.231
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