A catalytically silent FAAH-1 variant drives anandamide transport in neurons

The endocannabinoid anandamide is removed from the synaptic space by a selective transport system, expressed in neurons and astrocytes, which remains molecularly uncharacterized. Here we describe a partly cytosolic variant of the intracellular anandamide-degrading enzyme, fatty acid amide hydrolase-...

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Hauptverfasser: Fu, Jin, Bottegoni, Giovanni, Sasso, Oscar, Bertorelli, Rosalia, Rocchia, Walter, Masetti, Matteo, Guijarro, Ana, Lodola, Alessio, Armirotti, Andrea, Garau, Gianpiero, Bandiera, Tiziano, Reggiani, Angelo, Mor, Marco, Cavalli, Andrea, Piomelli, Daniele
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245783/
https://ncbi.nlm.nih.gov/pubmed/22101642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2986
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