Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance

The inhibitor of NF-κB (IκB) kinases (IKK1[α] and IKK2[β]), the catalytic subunits of the IKK complex, phosphorylate IκB proteins on serine residues, targeting them for degradation and thus activating the transcription factor NF-κB. More recently, IKK2 has been implicated in mediation of insulin res...

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Autores principales: Röhl, Mathias, Pasparakis, Manolis, Baudler, Stephanie, Baumgartl, Julia, Gautam, Dinesh, Huth, Marion, De Lorenzi, Rossana, Krone, Wilhelm, Rajewsky, Klaus, Brüning, Jens C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC324533/
https://ncbi.nlm.nih.gov/pubmed/14755344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418712
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