Role for neuronal insulin resistance in neurodegenerative diseases

Impairment of insulin signaling in the brain has been linked to neurodegenerative diseases. To test the hypothesis that neuronal insulin resistance contributes to defects in neuronal function, we have performed a detailed analysis of brain/neuron-specific insulin receptor knockout (NIRKO) mice. We f...

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Detalles Bibliográficos
Autores principales: Schubert, Markus, Gautam, Dinesh, Surjo, David, Ueki, Kojihiko, Baudler, Stephanie, Schubert, Dominic, Kondo, Tatsuya, Alber, Jens, Galldiks, Norbert, Küstermann, Eckehardt, Arndt, Saskia, Jacobs, Andreas H., Krone, Wilhelm, Kahn, C. Ronald, Brüning, Jens C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC365750/
https://ncbi.nlm.nih.gov/pubmed/14981233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308724101
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