Role for neuronal insulin resistance in neurodegenerative diseases

Impairment of insulin signaling in the brain has been linked to neurodegenerative diseases. To test the hypothesis that neuronal insulin resistance contributes to defects in neuronal function, we have performed a detailed analysis of brain/neuron-specific insulin receptor knockout (NIRKO) mice. We f...

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Dades bibliogràfiques
Autors principals: Schubert, Markus, Gautam, Dinesh, Surjo, David, Ueki, Kojihiko, Baudler, Stephanie, Schubert, Dominic, Kondo, Tatsuya, Alber, Jens, Galldiks, Norbert, Küstermann, Eckehardt, Arndt, Saskia, Jacobs, Andreas H., Krone, Wilhelm, Kahn, C. Ronald, Brüning, Jens C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC365750/
https://ncbi.nlm.nih.gov/pubmed/14981233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308724101
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