Role for neuronal insulin resistance in neurodegenerative diseases

Impairment of insulin signaling in the brain has been linked to neurodegenerative diseases. To test the hypothesis that neuronal insulin resistance contributes to defects in neuronal function, we have performed a detailed analysis of brain/neuron-specific insulin receptor knockout (NIRKO) mice. We f...

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Detalhes bibliográficos
Main Authors: Schubert, Markus, Gautam, Dinesh, Surjo, David, Ueki, Kojihiko, Baudler, Stephanie, Schubert, Dominic, Kondo, Tatsuya, Alber, Jens, Galldiks, Norbert, Küstermann, Eckehardt, Arndt, Saskia, Jacobs, Andreas H., Krone, Wilhelm, Kahn, C. Ronald, Brüning, Jens C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC365750/
https://ncbi.nlm.nih.gov/pubmed/14981233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308724101
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