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Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

Development of obesity-associated insulin resistance and diabetes mellitus type 2 has been linked to activation of proinflammatory pathways in the liver, leading to impaired insulin signal transduction. To further define the role of hepatic NF-κB activation in this process, we have analyzed glucose...

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Bibliografski detalji
Glavni autori: Wunderlich, F. Thomas, Luedde, Tom, Singer, Stephan, Schmidt-Supprian, Marc, Baumgartl, Julia, Schirmacher, Peter, Pasparakis, Manolis, Brüning, Jens C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234132/
https://ncbi.nlm.nih.gov/pubmed/18216263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707849104
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