Igλ(+) B cell development but not Igκ editing depends on NF-κB signals

By genetically ablating IκB kinase (IKK)-mediated NF-κB activation in the B cell lineage, and by analyzing a mouse mutant in which Igλ(+) B cells are generated in the absence of rearrangements in Igk, we define two distinct, consecutive phases of early B cell development that differ in their depende...

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Detalhes bibliográficos
Main Authors: Derudder, Emmanuel, Cadera, Emily J, Vahl, J Christoph, Wang, Jing, Fox, Casey J., Zha, Shan, van Loo, Geert, Pasparakis, Manolis, Schlissel, Mark S, Schmidt-Supprian, Marc, Rajewsky, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742984/
https://ncbi.nlm.nih.gov/pubmed/19412180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1732
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