Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells

Although canonical NF-κB signaling is crucial to generate a normal mature B-cell compartment, its role in the persistence of resting mature B cells is controversial. To resolve this conflict, we ablated NF-κB essential modulator (NEMO) and IκB kinase 2 (IKK2), two essential mediators of the canonica...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Derudder, Emmanuel, Herzog, Sebastian, Labi, Verena, Yasuda, Tomoharu, Köchert, Karl, Janz, Martin, Villunger, Andreas, Schmidt-Supprian, Marc, Rajewsky, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983837/
https://ncbi.nlm.nih.gov/pubmed/27099294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1604529113
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