TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells

Upon activation by antigen, B cells form germinal centres where they clonally expand and introduce affinity‐enhancing mutations into their B‐cell receptor genes. Somatic mutagenesis and class switch recombination (CSR) in germinal centre B cells are initiated by the activation‐induced cytidine deami...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:FEBS J
Main Authors: Schoeler, Katia, Aufschnaiter, Andreas, Messner, Simon, Derudder, Emmanuel, Herzog, Sebastian, Villunger, Andreas, Rajewsky, Klaus, Labi, Verena
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2019
Teme:
Editor's Choice
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851767/
https://ncbi.nlm.nih.gov/pubmed/31120187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14934
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