Major differences in the responses of primary human leukocyte subsets to IFN-β()

Treatment of cell lines with type I IFNs activates the formation of ISGF3 (STAT1/STAT2/IRF9), which induces the expression of many genes. To study this response in primary cells, we treated fresh human blood with IFN-β and used flow cytometry to analyze phosphorylated STATs1, 3 and 5 in CD4(+) and C...

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Bibliographic Details
Main Authors: van Boxel-Dezaire, Anette H. H., Zula, Joana A., Xu, Yaomin, Ransohoff, Richard M., Jacobberger, James W., Stark, George R.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3244975/
https://ncbi.nlm.nih.gov/pubmed/20956346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902314
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