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STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
The activation of STAT3 by tyrosine phosphorylation, essential for normal development and for a normal inflammatory response to invading pathogens, is kept in check by negative regulators. Abnormal constitutive activation of STAT3, which contributes to the pathology of cancer and to chronic inflamma...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3801081/ https://ncbi.nlm.nih.gov/pubmed/24082147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315862110 |
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