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Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

In normal human cells treated with interferons (IFNs), the concentration of tyrosine-phosphorylated STAT1 (YP-STAT1), which drives the expression of a large number of genes, increases quickly but then decreases over a period of several hours. Because the STAT1 gene is activated by YP-STAT1, IFNs sti...

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Autores principales: Cheon, HyeonJoo, Stark, George R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688000/
https://ncbi.nlm.nih.gov/pubmed/19478064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903487106
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