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Genomic and Molecular Characterization of Malignant Peripheral Nerve Sheath Tumor Identifies the IGF1R Pathway as a Primary Target for Treatment

PURPOSE: Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks effective therapeutic strategies. We gain insight into the most recurrent genetically altered pathways with the purpose of scanning possible therapeutic targets. EXPERIMENTAL DESIGN: We performed a microarray based...

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Detalhes bibliográficos
Main Authors: Yang, Jilong, Ylipää, Antti, Sun, Yan, Zheng, Hong, Chen, Kexin, Nykter, Matti, Trent, Jonathan, Ratner, Nancy, Lev, Dina C., Zhang, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243813/
https://ncbi.nlm.nih.gov/pubmed/22042973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1707
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