APC/C(Cdh1)-Mediated Degradation of the F-Box Protein NIPA Is Regulated by Its Association with Skp1

NIPA (Nuclear Interaction Partner of Alk kinase) is an F-box like protein that targets nuclear Cyclin B1 for degradation. Integrity and therefore activity of the SCF(NIPA) E3 ligase is regulated by cell-cycle-dependent phosphorylation of NIPA, restricting substrate ubiquitination to interphase. Here...

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Bibliographic Details
Main Authors: von Klitzing, Christine, Huss, Richard, Illert, Anna Lena, Fröschl, Astrid, Wötzel, Sabine, Peschel, Christian, Bassermann, Florian, Duyster, Justus
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243670/
https://ncbi.nlm.nih.gov/pubmed/22205987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028998
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