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The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

The ordered progression through the cell cycle depends on regulating the abundance of several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and specific. One key component of the degradation system, the anaphase promoting complex (APC), is a ubiquitin protein ligase...

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Autors principals: Pfleger, Cathie M., Kirschner, Marc W.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC316466/
https://ncbi.nlm.nih.gov/pubmed/10733526
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