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Receptor Binding Enables Botulinum Neurotoxin B to Sense Low pH for Translocation Channel Assembly

Botulinum neurotoxins (BoNTs, serotypes A-G), elaborated by Clostridium botulinum, can induce lethal paralysis and are classified as category-A bioterrorism agents. However, how BoNTs translocate from endosomes into the cytosol of neurons to gain access to their intracellular targets remains enigmat...

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Main Authors: Sun, Shihu, Suresh, Swetha, Liu, Huisheng, Tepp, William H., Johnson, Eric A., Edwardson, J. Michael, Chapman, Edwin R.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243646/
https://ncbi.nlm.nih.gov/pubmed/21925111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.06.012
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