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Botulinum Neurotoxins B and E Translocate at Different Rates and Exhibit Divergent Responses to GT1b and Low pH

[Image: see text] Botulinum neurotoxins (BoNTs, serotypes A–G) are the most deadly substances known. Here, we investigated how BoNT/E, a serotype that causes human botulism, translocates into the cytosol of neurons. Analogous to BoNT/B, BoNT/E required binding of the coreceptor, GT1b, to undergo sig...

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Autors principals: Sun, Shihu, Tepp, William H., Johnson, Eric A., Chapman, Edwin R.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398548/
https://ncbi.nlm.nih.gov/pubmed/22720883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3004928
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