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Botulinum Neurotoxins B and E Translocate at Different Rates and Exhibit Divergent Responses to GT1b and Low pH
[Image: see text] Botulinum neurotoxins (BoNTs, serotypes A–G) are the most deadly substances known. Here, we investigated how BoNT/E, a serotype that causes human botulism, translocates into the cytosol of neurons. Analogous to BoNT/B, BoNT/E required binding of the coreceptor, GT1b, to undergo sig...
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| 主要な著者: | , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2012
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3398548/ https://ncbi.nlm.nih.gov/pubmed/22720883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3004928 |
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