Structural and Functional Analysis of Botulinum Neurotoxin subunits for pH-dependent Membrane Channel Formation and Translocation

The structure–function relationship of Botulinum Neurotoxin (BoNT) proteins is greatly influenced by pH. While the low pH of endosome favors membrane interaction of the heavy chain (HC) for formation of a membrane channel and translocation of the light chain (LC), the catalytic activity of the LC re...

Full description

Saved in:
Bibliographic Details
Published in:Biochim Biophys Acta
Main Authors: Chellappan, Gowri, Kumar, Raj, Santos, Erin, Goyal, Dipak, Cai, Shuowei, Singh, Bal Ram
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573437/
https://ncbi.nlm.nih.gov/pubmed/26012869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.05.013
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items