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Structural and Functional Analysis of Botulinum Neurotoxin subunits for pH-dependent Membrane Channel Formation and Translocation
The structure–function relationship of Botulinum Neurotoxin (BoNT) proteins is greatly influenced by pH. While the low pH of endosome favors membrane interaction of the heavy chain (HC) for formation of a membrane channel and translocation of the light chain (LC), the catalytic activity of the LC re...
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| Publicado no: | Biochim Biophys Acta |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4573437/ https://ncbi.nlm.nih.gov/pubmed/26012869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.05.013 |
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