The Thiazide-sensitive NaCl Cotransporter Is Targeted for Chaperone-dependent Endoplasmic Reticulum-associated Degradation

The thiazide-sensitive NaCl cotransporter (NCC, SLC12A3) mediates salt reabsorption in the distal nephron of the kidney and is the target of thiazide diuretics, which are commonly prescribed to treat hypertension. Mutations in NCC also give rise to Gitelman syndrome, a hereditary salt-wasting disord...

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Main Authors: Needham, Patrick G., Mikoluk, Kasia, Dhakarwal, Pradeep, Khadem, Shaheen, Snyder, Avin C., Subramanya, Arohan R., Brodsky, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243568/
https://ncbi.nlm.nih.gov/pubmed/22027832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288928
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