The Thiazide-sensitive NaCl Cotransporter Is Targeted for Chaperone-dependent Endoplasmic Reticulum-associated Degradation

The thiazide-sensitive NaCl cotransporter (NCC, SLC12A3) mediates salt reabsorption in the distal nephron of the kidney and is the target of thiazide diuretics, which are commonly prescribed to treat hypertension. Mutations in NCC also give rise to Gitelman syndrome, a hereditary salt-wasting disord...

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Detaylı Bibliyografya
Asıl Yazarlar: Needham, Patrick G., Mikoluk, Kasia, Dhakarwal, Pradeep, Khadem, Shaheen, Snyder, Avin C., Subramanya, Arohan R., Brodsky, Jeffrey L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Membrane Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243568/
https://ncbi.nlm.nih.gov/pubmed/22027832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.288928
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