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Degradation of p21(Cip1) through Anaphase-promoting Complex/Cyclosome and Its Activator Cdc20 (APC/C(Cdc20)) Ubiquitin Ligase Complex-mediated Ubiquitylation Is Inhibited by Cyclin-dependent Kinase 2 in Cardiomyocytes
Cyclin-dependent kinase inhibitor p21(Cip1) plays a crucial role in regulating cell cycle arrest and differentiation. It is known that p21(Cip1) increases during terminal differentiation of cardiomyocytes, but its expression control and biological roles are not fully understood. Here, we show that t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3243522/ https://ncbi.nlm.nih.gov/pubmed/22045811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236711 |
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