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Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell-cycle regulatory proteins during exit from mitosis and in the G(1) phase of the cell cycle. The activity of APC/C in mitosis and in G(1) requires interaction with the activat...

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Autori principali: Eytan, Esther, Moshe, Yakir, Braunstein, Ilana, Hershko, Avram
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413726/
https://ncbi.nlm.nih.gov/pubmed/16455800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510695103
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