Degradation of p21(Cip1) through Anaphase-promoting Complex/Cyclosome and Its Activator Cdc20 (APC/C(Cdc20)) Ubiquitin Ligase Complex-mediated Ubiquitylation Is Inhibited by Cyclin-dependent Kinase 2 in Cardiomyocytes

Cyclin-dependent kinase inhibitor p21(Cip1) plays a crucial role in regulating cell cycle arrest and differentiation. It is known that p21(Cip1) increases during terminal differentiation of cardiomyocytes, but its expression control and biological roles are not fully understood. Here, we show that t...

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Detalhes bibliográficos
Main Authors: Yamada, Kazuhiko, Tamamori-Adachi, Mimi, Goto, Ikuko, Iizuka, Masayoshi, Yasukawa, Takashi, Aso, Teijiro, Okazaki, Tomoki, Kitajima, Shigetaka
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243522/
https://ncbi.nlm.nih.gov/pubmed/22045811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.236711
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