Differential Effects of Etomidate and its Pyrrole Analogue Carboetomidate on the Adrenocortical and Cytokine Responses to Endotoxemia

OBJECTIVE: We developed a novel pyrrole analogue of etomidate, (R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate (carboetomidate), which retains etomidate’s desirable anesthetic and hemodynamic properties but lacks its potent inhibitory affect on adrenocorticotropic hormone-stimulated steroid syn...

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Hlavní autoři: Pejo, Ervin, Feng, Yan, Chao, Wei, Cotten, Joseph F, Ge, Ri Le, Raines, Douglas E
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242859/
https://ncbi.nlm.nih.gov/pubmed/21926608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0b013e31822d7924
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