Mechanisms of Ligand Binding to the Parathyroid Hormone (PTH)/PTH-Related Protein Receptor: Selectivity of a Modified PTH(1–15) Radioligand for Gα(S)-Coupled Receptor Conformations

Mechanisms of ligand binding to the PTH/PTHrP receptor (PTHR) were explored using PTH fragment analogs as radioligands in binding assays. In particular, the modified amino-terminal fragment analog, (125)I-[Aib(1,3),Nle(8),Gln (10),homoarginine(11),Ala(12) Trp(14),Tyr(15)]rPTH(1–15)NH(2), (125)I-[Aib...

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Detalhes bibliográficos
Main Authors: Dean, Thomas, Linglart, Agnes, Mahon, Matthew J., Bastepe, Murat, Jüppner, Harald, Potts, John T., Gardella, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242416/
https://ncbi.nlm.nih.gov/pubmed/16339275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2005-0349
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