An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen’s Metaphyseal Chondrodysplasia

Jansen’s metaphyseal chondrodysplasia (JMC) is a rare disease of bone and mineral ion physiology that is caused by activating mutations in PTHR1. Ligand-independent signaling by the mutant receptors in cells of bone and kidney results in abnormal skeletal growth, excessive bone turnover, and chronic...

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Vydáno v:J Bone Miner Res
Hlavní autoři: Noda, Hiroshi, Guo, Jun, Khatri, Ashok, Dean, Thomas, Reyes, Monica, Armanini, Michael, Brooks, Daniel J, Martins, Janaina S, Schipani, Ernestina, Bouxsein, Mary L, Demay, Marie B, Potts, John T, Jüppner, Harald, Gardella, Thomas J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8050614/
https://ncbi.nlm.nih.gov/pubmed/31693237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.3913
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