Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog (LA‐PTH)

Prolonged signaling at the parathyroid hormone receptor 1 (PTHR1) correlates with the capacity of a ligand to bind to a G protein‐independent receptor conformation (R(0)). As long‐acting PTH (LA‐PTH) ligands hold interest as potential treatments for hypoparathyroidism (HP), we explored the structura...

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Detalhes bibliográficos
Publicado no:JBMR Plus
Main Authors: Noda, Hiroshi, Okazaki, Makoto, Joyashiki, Eri, Tamura, Tatsuya, Kawabe, Yoshiki, Khatri, Ashok, Jueppner, Harald, Potts, John T, Gardella, Thomas J, Shimizu, Masaru
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7340446/
https://ncbi.nlm.nih.gov/pubmed/32666018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10367
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