Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH

Agonist-induced phosphorylation of the parathyroid hormone (PTH) receptor 1 (PTHR1) regulates receptor signaling in vitro, but the role of this phosphorylation in vivo is uncertain. We investigated this role by injecting “knock-in” mice expressing a phosphorylation-deficient (PD) PTHR1 with PTH liga...

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Detalhes bibliográficos
Main Authors: Maeda, Akira, Okazaki, Makoto, Baron, David M., Dean, Thomas, Khatri, Ashok, Mahon, Mathew, Segawa, Hiroko, Abou-Samra, Abdul B., Jüppner, Harald, Bloch, Kenneth D., Potts, John T., Gardella, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625299/
https://ncbi.nlm.nih.gov/pubmed/23533279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301674110
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