Acute Down-regulation of Sodium-dependent Phosphate Transporter NPT2a Involves Predominantly the cAMP/PKA Pathway as Revealed by Signaling-selective Parathyroid Hormone Analogs

The parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTHR1) in cells of the renal proximal tubule mediates the reduction in membrane expression of the sodium-dependent P(i) co-transporters, NPT2a and NPT2c, and thus suppresses the re-uptake of P(i) from the filtrate. In most cell type...

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Detalhes bibliográficos
Main Authors: Nagai, So, Okazaki, Makoto, Segawa, Hiroko, Bergwitz, Clemens, Dean, Thomas, Potts, John T., Mahon, Matthew J., Gardella, Thomas J., Jüppner, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020770/
https://ncbi.nlm.nih.gov/pubmed/21047792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.198416
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