Parathyroid hormone(1–34) and its analogs differentially modulate osteoblastic Rankl expression via PKA/SIK2/SIK3 and PP1/PP2A–CRTC3 signaling

Osteoporosis can result from the loss of sex hormones and/or aging. Abaloparatide (ABL), an analog of parathyroid hormone–related protein (PTHrP(1–36)), is the second osteoanabolic therapy approved by the United States Food and Drug Administration after teriparatide (PTH(1–34)). All three peptides b...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ricarte, Florante R., Le Henaff, Carole, Kolupaeva, Victoria G., Gardella, Thomas J., Partridge, Nicola C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6311504/
https://ncbi.nlm.nih.gov/pubmed/30377251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004751
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