SIKs control osteocyte responses to parathyroid hormone

Parathyroid hormone (PTH) activates receptors on osteocytes to orchestrate bone formation and resorption. Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2. Salt inducib...

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Publicado en:Nat Commun
Main Authors: Wein, Marc N., Liang, Yanke, Goransson, Olga, Sundberg, Thomas B., Wang, Jinhua, Williams, Elizabeth A., O'Meara, Maureen J., Govea, Nicolas, Beqo, Belinda, Nishimori, Shigeki, Nagano, Kenichi, Brooks, Daniel J., Martins, Janaina S., Corbin, Braden, Anselmo, Anthony, Sadreyev, Ruslan, Wu, Joy Y., Sakamoto, Kei, Foretz, Marc, Xavier, Ramnik J., Baron, Roland, Bouxsein, Mary L., Gardella, Thomas J., Divieti-Pajevic, Paola, Gray, Nathanael S., Kronenberg, Henry M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075806/
https://ncbi.nlm.nih.gov/pubmed/27759007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13176
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