HDAC5 controls MEF2C-driven sclerostin expression in osteocytes

Osteocytes secrete paracrine factors that regulate the balance between bone formation and destruction. Among these molecules, sclerostin (encoded by the gene SOST) inhibits osteoblastic bone formation, and is an osteoporosis drug target. The molecular mechanisms underlying SOST expression remain lar...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Wein, Marc N., Spatz, Jordan, Nishimori, Shigeki, Doench, John, Root, David, Babij, Philip, Nagano, Kenichi, Baron, Roland, Brooks, Daniel, Bouxsein, Mary, Pajevic, Paola Divieti, Kronenberg, Henry M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342334/
https://ncbi.nlm.nih.gov/pubmed/25271055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.2381
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