Llwytho...

Loss of Gsα in osteocytes leads to osteopenia due to sclerostin induced suppression of osteoblast activity

The stimulatory subunit of G-protein, Gsα, acts as a secondary messenger of G-protein coupled receptors (GPCRs) that primarily activates cAMP-induced signaling. GPCRs, such as the parathyroid receptor (PTHR), are critical regulators of bone formation as shown by number of genetic manipulation studie...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bone
Prif Awduron: Fulzele, Keertik, Dedic, Christopher, Lai, Forest, Bouxsein, Mary, Lotinun, Sutada, Baron, Roland, Divieti Pajevic, Paola
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207374/
https://ncbi.nlm.nih.gov/pubmed/30266511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2018.09.021
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