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Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation

The parathyroid hormone receptor (PTHR) is a class B G protein-coupled receptor that plays critical roles in bone and mineral ion metabolism. Ligand binding to the PTHR involves interactions to both the amino-terminal extracellular (N) domain, and transmembrane/extracellular loop, or juxtamembrane (...

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Autori principali: Okazaki, Makoto, Ferrandon, Sebastien, Vilardaga, Jean-Pierre, Bouxsein, Mary L., Potts, John T., Gardella, Thomas J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571912/
https://ncbi.nlm.nih.gov/pubmed/18946036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808750105
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