Structural Basis for Parathyroid Hormone-related Protein Binding to the Parathyroid Hormone Receptor and Design of Conformation-selective Peptides

Parathyroid hormone (PTH) and PTH-related protein (PTHrP) are two related peptides that control calcium/phosphate homeostasis and bone development, respectively, through activation of the PTH/PTHrP receptor (PTH1R), a class B G protein-coupled receptor. Both peptides hold clinical interest for their...

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Bibliographic Details
Main Authors: Pioszak, Augen A., Parker, Naomi R., Gardella, Thomas J., Xu, H. Eric
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788887/
https://ncbi.nlm.nih.gov/pubmed/19674967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.022905
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