Dimeric Arrangement of the Parathyroid Hormone Receptor and a Structural Mechanism for Ligand-induced Dissociation

The parathyroid hormone receptor (PTH1R) is a class B G protein-coupled receptor that is activated by parathyroid hormone (PTH) and PTH-related protein (PTHrP). Little is known about the oligomeric state of the receptor and its regulation by hormone. The crystal structure of the ligand-free PTH1R ex...

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Main Authors: Pioszak, Augen A., Harikumar, Kaleeckal G., Parker, Naomi R., Miller, Laurence J., Xu, H. Eric
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852981/
https://ncbi.nlm.nih.gov/pubmed/20172855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.093138
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