Structural Basis for Hormone Recognition by the Human CRFR2α G Protein-coupled Receptor

The mammalian corticotropin releasing factor (CRF)/urocortin (Ucn) peptide hormones include four structurally similar peptides, CRF, Ucn1, Ucn2, and Ucn3, that regulate stress responses, metabolism, and cardiovascular function by activating either of two related class B G protein-coupled receptors,...

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Hlavní autoři: Pal, Kuntal, Swaminathan, Kunchithapadam, Xu, H. Eric, Pioszak, Augen A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001015/
https://ncbi.nlm.nih.gov/pubmed/20966082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186072
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