Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage

Human polynucleotide kinase/phosphatase (PNKP) is a dual specificity 5′-DNA kinase/3′-DNA phosphatase, with roles in base excision repair, DNA single-strand break repair and non-homologous end joining (NHEJ); yet precisely how PNKP functions in the repair of DNA double strand breaks (DSBs) remains u...

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Detalhes bibliográficos
Main Authors: Zolner, Angela E., Abdou, Ismail, Ye, Ruiqiong, Mani, Rajam S., Fanta, Mesfin, Yu, Yaping, Douglas, Pauline, Tahbaz, Nasser, Fang, Shujuan, Dobbs, Tracey, Wang, Chen, Morrice, Nick, Hendzel, Michael J., Weinfeld, Michael, Lees-Miller, Susan P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241656/
https://ncbi.nlm.nih.gov/pubmed/21824916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr647
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