Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage

Human polynucleotide kinase/phosphatase (PNKP) is a dual specificity 5′-DNA kinase/3′-DNA phosphatase, with roles in base excision repair, DNA single-strand break repair and non-homologous end joining (NHEJ); yet precisely how PNKP functions in the repair of DNA double strand breaks (DSBs) remains u...

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Hlavní autoři: Zolner, Angela E., Abdou, Ismail, Ye, Ruiqiong, Mani, Rajam S., Fanta, Mesfin, Yu, Yaping, Douglas, Pauline, Tahbaz, Nasser, Fang, Shujuan, Dobbs, Tracey, Wang, Chen, Morrice, Nick, Hendzel, Michael J., Weinfeld, Michael, Lees-Miller, Susan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241656/
https://ncbi.nlm.nih.gov/pubmed/21824916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr647
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