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Complexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site

Structural results with minor groove binding agents, such as netropsin, have provided detailed, atomic level views of DNA molecular recognition. Solution studies, however, indicate that there is complexity in the binding of minor groove agents to a single site. Netropsin, for example, has two DNA bi...

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Main Authors: Lewis, Edwin A., Munde, Manoj, Wang, Shuo, Rettig, Michael, Le, Vu, Machha, Venkata, Wilson, W. David
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3239193/
https://ncbi.nlm.nih.gov/pubmed/21890907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr699
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