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Configurational Entropy Change of Netropsin and Distamycin upon DNA Minor-Groove Binding
Binding of a small molecule to a macromolecular target reduces its conformational freedom, resulting in a negative entropy change that opposes the binding. The goal of this study is to estimate the configurational entropy change of two minor-groove-binding ligands, netropsin and distamycin, upon bin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1518646/ https://ncbi.nlm.nih.gov/pubmed/16731550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.074617 |
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