Single-cell dissection of transcriptional heterogeneity in human colon tumors

Cancer is often viewed as a caricature of normal developmental processes, but the extent by which its cellular heterogeneity truly recapitulates multi-lineage differentiation processes of normal tissues remains unknown. Here, we implement “single-cell PCR gene-expression analysis” (SINCE-PCR) to dis...

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Détails bibliographiques
Auteurs principaux: Dalerba, Piero, Kalisky, Tomer, Sahoo, Debashis, Rajendran, Pradeep S., Rothenberg, Michael E., Leyrat, Anne A., Sim, Sopheak, Okamoto, Jennifer, Johnston, Darius M., Qian, Dalong, Zabala, Maider, Bueno, Janet, Neff, Norma F., Wang, Jianbin, Shelton, Andrew A., Visser, Brendan, Hisamori, Shigeo, Shimono, Yohei, van de Wetering, Marc, Clevers, Hans, Clarke, Michael F., Quake, Stephen R.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237928/
https://ncbi.nlm.nih.gov/pubmed/22081019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2038
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