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CTLA-4 regulates pathogenicity of antigen-specific autoreactive T cells by cell-intrinsic and -extrinsic mechanisms
CTLA-4 is critical in maintaining self-tolerance but the mechanisms of its actions have been controversial. Here, we examined the antigen-specificity of tissue-infiltrating CD4(+) T cells in CTLA-4(−/−) mice and determined the in vivo cellular targets of CTLA-4. Tissue-infiltrating CTLA-4(−/−) T cel...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3235641/ https://ncbi.nlm.nih.gov/pubmed/20037585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1835 |
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