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In CD4(+) T-Cell-Induced Diabetes, Macrophages Are the Final Effector Cells that Mediate Islet β-Cell Killing : Studies from an Acute Model
To understand better how diabetogenic CD4(+) T cells induce islet β-cell death and cause diabetes, a transfer model of acute diabetes using the diabetogenic CD4(+) BDC2.5 T-cell clone was established. Transfer of activated BDC T cells into NOD.scid mice resulted in diabetes within a week, characteri...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1762478/ https://ncbi.nlm.nih.gov/pubmed/17148676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.060539 |
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